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Molecular Pharmacology, Vol 1, 107-109, Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics

Biosynthesis of Highly Labeled Actinomycins

EDWARD KATZ 1, ANTHONY B. MAUGER 1, and HERBERT WEISSBACH 1

1 Department of Microbiology, Georgetown University Schools of Medicine and Dentistry, Washington 7, D. C., and Laboratory of Clinical Biochemistry, National Heart Institute, and Laboratory of Chemistry, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland

The synthesis of tritiated actinomycin having a specific activity of 80,000 cpm/µg has been accomplished by growing Streptomyces antibioticus in the presence of methyl labeled L-methionine.

Submitted on March 15, 1965
Revised on April 1, 1965






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