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Molecular Pharmacology, Vol 1, 239-246, Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics

Metabolism of Trichloroethylene in Liver Microsomes

I. Characteristics of the Reaction

KENNETH C. LEIBMAN 1

1 Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida

The conversion of trichloroethylene to chloral hydrate was shown to take place in liver microsomes of rats, rabbits, and dogs, in a reaction requiring NADPH and oxygen. A stable, lyophilized preparation of microsomal and soluble fractions of liver homogenates in Tris buffer was used, from which a fraction could be obtained which resembled fresh microsomes in behavior. The effects of a number of activators and inhibitors of the enzyme system are described.

Note:
ACKNOWLEDGMENTS It is a pleasure to acknowledge the excellent technical assistance of Miss Elsa Ortiz. This work was supported in part by U.S. Public Health Service Research Grant No. OH-00124.

Submitted on July 19, 1965






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