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Molecular Pharmacology, Vol 1, 247-254, Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics

Metabolism of Trichloroethylene in Liver Microsomes

II. Identification of the Reaction Product as Chloral Hydrate

KEITH H. BYINGTON 1 and KENNETH C. LEIBMAN 1

1 Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida

The product of metabolism of trichloroethylene in rat liver microsomes has been characterized as chloral hydrate. In common with chloral hydrate, the metabolite is converted to dichloroacetic acid upon reaction with basic cyanide; to chloroglyoxal bis-2,4-dinitrophenylhydrazone upon treatment with 2,4-dinitrophenylhydrazine in acid; to trichloroethanol by the action of liver alcohol dehydrogenase; and to trichloroacetic acid upon oxidation mediated by chloral hydrate dehydrogenase. Possible mechanisms of the conversion of trichloroethylene to chloral hydrate are discussed.

Note:
ACKNOWLEDGMENTS The authors are greatly indebted to Mr. Howard J. Lambert for aid in gas chromatography, and to him and Dr. E. R. Garrett for making available to them their chromatographic method in advance of publication. They also acknowledge the technical assistance of Mr. James D. Hindman in developing colorimetric methods. This work was supported in Part by U. S. Public Health Service Research Grant No. OH-00124.

Submitted on July 19, 1965




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Carcinogenicity of Chloral Hydrate Administered in Drinking Water to the Male F344/N Rat and Male B6C3F1 Mouse
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