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Molecular Pharmacology, Vol 1, 312-313, Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics

Graphic Differentiation between Competitive and Functional Synergism

ALEXANDER GERO 1

1 Department of Pharmacology, Hahnemann Medical College, Philadelphia, Pennsylvania

A graphic method is presented which permits one to differentiate between otherwise indistinguishable dose-effect plots of drugs displaying competitive synergism (both drugs acting on the same receptor) and functional synergism (drugs acting on different receptors linked to the same effector system).

Submitted on September 22, 1965






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