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Molecular Pharmacology, Vol 10, 68-77, Copyright © 1974 by the American Society for Pharmacology and Experimental Therapeutics

Comparative Inhibitory Action of D- and L-Tryptophan on the Effect of d-Lysergic Acid Diethylamide in Vitro

JEFFREY L. WINKELHAKE 1, EDWARD W. VOSS JR. 1, and DENNIS E. LOPATIN 1

1 Department of Microbiology, University of Illinois, Urbana, Illinois 61801

The incorporation in vitro of d-[3H]lysergic acid diethylamide into secreted protein from hyperimmune rabbit lymphoid cells was inhibited by both D- and L-tryptophan. The inhibition was specific for tryptophan isomers and analogues. On the basis of these findings a pathway was formulated to describe the preliminary steps culminating in the covalent incorporation of lysergic acid diethylamide into synthesized protein.

Submitted on September 10, 1973






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