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Molecular Pharmacology, Vol 10, 315-318, Copyright © 1974 by the American Society for Pharmacology and Experimental Therapeutics

Addendum

Multiple Regression Analyses of the Relationship between Structure and Inhibitory Effects of a Series of Substituted O-Phenyl-DL-homoserines on Adenosine Triphosphate:L-Methionine S-Adenosyltransferase

PETER B. HULBERT 1

1 Department of Pathobiology, The Johns Hopkins School of Hygiene and Public Health, and Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

The correlation among the inhibitory potencies for rat liver ATP:L-methionine S-adenosyltransferase of a series of 11 substituted O-phenyl-DL-homoserines and various Hammett sgr and Hansch pgr coefficients has been examined. Regression analyses by the method of least squares gave the best correlation by the use of a linear combination of ordinary sgr values and pgr values for phenoxyacetic acid derivatives. The analysis gave the linear free energy relationship pI50 = 0.619pgr + 0.614sgr + 1.62 for n = 11. The correlation coefficient of r = 0.989 inidicated that an almost complete correspondence of structural properties with potency was achieved

Submitted on August 20, 1973






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