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Molecular Pharmacology, Vol 11, 879-882, Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics

Biphasic Effects of Halothane on Phospholipid and Synaptic Plasma Membranes: a Spin Label Study

PER H. ROSENBERG 1, HANSJÖRG EIBL 1, and ANTON STIER 1

1 Max-Planck Institute of Biophysical Chemistry, D-3400 Göttingen, German Federal Republic

Halothane at 0.16 and 0.32 mM increased, while at 9.3 mM it decreased, the order parameter in palmitoyllauroyllecithin vesicles containing stearic acid spin label I(12,3). A corresponding effect was seen in rat brain synaptic plasma membranes. In dipalmitoyllecithin vesicles the lateral diffusion of stearic acid spin label I(5,10) was inhibited by halothane at 0.32-1.60 mM and promoted by it at 9.3 mM. Halothane in these three membrane systems exerted a biphasic effect, low concentrations ordering and high concentrations disordering the lipid structure of the membranes.

Note:
ACKNOWLEDGMENTS We thank Dr. W. Kühnle for the synthesis of androstane spin label.

Submitted on April 1, 1975






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