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Molecular Pharmacology, Vol 13, 113-121, Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics

Solvent Effects on Halothane: 19F Nuclear Magnetic Resonance in Solvents and Artificial Membranes

LYNDA S. KOEHLER 1, WINIFRED CURLEY 1, and KARL A. KOEHLER 1

1 Departments of Anesthesiology, Pathology, and Biochemistry, Division of Health Affairs, University of North Carolina, Chapel Hill, North Carolina 27514

This study of solvent effects on halothane 19F nuclear magnetic resonance chemical shifts was undertaken in order to elucidate environmental factors contributing to observed halothane 19F NMR shifts in the presence of phospholipid suspensions in aqueous media. Halothane 19F NMR chemical shifts are correlated by Hildebrand’s dgr function or refractive index for non-hydrogen-bonding solvents. No significant correlation was observed for other solvent properties, such as dielectric constant. Water and alcohols show positive deviations from the correlation with dgr. Halothane molecules associated with both synthetic and natural phospholipid multilayer vesicles show significant line broadening of the fluorine signal and appear to be in an environment which may be characterized by a dgr value of 9.3 ± 0.3 (cal/cm3)1/2 by comparison with the observed correlation of chemical shift with dgr in isotropic solvent systems.

Note:
ACKNOWLEDGMENTS The authors express their appreciation to Drs. P. D. Ellis, E. T. Fossel, W. Freeman, M. K. Jain, C. N. Reilley, A. K. Solomon, and K. Sugioka for simultaneously discouraging, helpful, and stimulating conversations, and to Dr. D. Harris for obtaining spectra on the XL-100 spectrometer.

Submitted on May 31, 1976
Accepted on August 27, 1976




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