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Molecular Pharmacology, Vol 13, 621-624, Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics

Nuclear Magnetic Resonance Studies of the Enzymatic Hydrolysis of Acetylcholine: a Critical Comment

K. S. KRISHNAN 1 and P. BALARAM 1

1 Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

Studies at 100 MHz of the hydrolysis of acetylcholine by brain membrane-bound acetylcholinesterase show that the N-methyl resonance acquires a doublet character as the hydrolysis proceeds. These results provide a simple explanation for the time-dependent NMR line broadening observed earlier for the interaction of acetylcholine with purified acetylcholinesterase.

Note:
ACKNOWLEDGMENT We thank the Department of Organic Chemistry, Indian Institute of Science, for use of the HA-100 spectrometer.

Submitted on December 22, 1976
Accepted on February 24, 1977






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Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics