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Molecular Pharmacology, Vol 13, 980-984, Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics

Anti-herpes Activity of Deoxythymidine Analogues: Specific Dependence on Virus-Induced Deoxythymidine Kinase

E. DE CLERCQ 1, E. KRAJEWSKA 1, J. DESCAMPS 1, and P. F. TORRENCE 1

1 Rega Institute for Medical Research, University of Leuven, B-3000 Leuven, Belgium

In both primary rabbit kidney and human skin fibroblasts, the replication of a particular herpes simplex virus, HSV-1 (strain KOS), is markedly inhibited by a wide variety of pyrimidine deoxyribo- and arabinonucleosides, while another herpes simplex virus, HSV-2 (strain 333), is not affected by any of the pyrimidine nucleoside analogues. The differential responsiveness of the two herpes virus strains to the antiviral effects of the nucleoside analogues could be accounted for by the presence or absence of viral deoxythymidine kinase in the infected cell, since HSV-1 (KOS) was found to induce deoxythymidine-deoxycytidine kinase activity in both primary rabbit kidney and human skin fibroblasts, whereas HSV-2 (333) failed to do so.

Note:
ACKNOWLEDGMENTS Samples of the stock viruses HSV-1 (strain KOS) and HSV-2 (strain 333) were kindly provided by Dr. J. Desmyter. We thank Miette Stuyck for excellent technical assistance.

Submitted on March 16, 1977
Accepted on May 5, 1977




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E. DE CLERCQ, J. DESCAMPS, P. DE SOMER, and A. HOLYacute
(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity
Science, May 5, 1978; 200(4341): 563 - 565.
[Abstract] [PDF]


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