Molecular Pharmacology, Vol 13, 1086-1091, Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics

Effects of ⁹-Tetrahydrocannabinol on Lymphocyte and Synaptosomal Lysophosphatidylcholine Acyltransferases in Vivo

¹ Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1

⁹-Tetrahydrocannabinol was administered to mice intravenously at 15-70 mg/kg. Two hours later the effect of the drug in vivo on brain synaptosomes and spleen lymphocytes was determined. Inhibition of acyl-CoA-lysophosphatidylcholine acyltransferase was significant in the synaptosome (maximum inhibition, 44%) and lymphocyte preparations (maximum inhibition, 24%). In lymphocytes there was concomitant inhibition of blastogenesis as measured by [³H]thymidine incorporation.

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ACKNOWLEDGMENT The authors thank Health and Welfare Canada for the gift of cannabinoids.