MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ENJALBERT, A.
Right arrow Articles by BOCKAERT, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ENJALBERT, A.
Right arrow Articles by BOCKAERT, J.

Molecular Pharmacology, Vol 14, 2-10, Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics

Postsynaptic Serotonin-Sensitive Adenylate Cyclase in the Central Nervous System

I. Development and Distribution of Serotonin and Dopamine-Sensitive Adenylate Cyclases in Rat and Guinea Pig Brain

ALAIN ENJALBERT 1, SYLVIE BOURGOIN 1, MICHEL HAMON 1, JOËLLE ADRIEN 1, and JOËL BOCKAERT 1

1 Laboratoire de Physiologie Cellulaire and Groupe NB, Institut National de la Santé et de la Recherche Médicale U114, Collège de France, 75231 Paris, and Unité de Recherches Neurophysiologiques, Institut National de la Santé et de la Recherche Médicale U3, 75013 Paris, France

Postsynaptic serotonin-sensitive adenylate cyclase with an apparent affinity of 1 µM for serotonin (5-HT) was detected in various structures of the central nervous system in the rat and the guinea pig. At birth, the regional distribution of this enzyme in the rat brain was closely correlated with the topographical distribution of the serotoninergic innervation in young (9-day-old) as well as adult animals. Electrolytic raphe lesions made on the fourth day after birth, which produced 90% degeneration of serotoninergic innervation in rat colliculi, did not alter the characteristics (apparent affinity and maximal activity) of the serotonin-sensitive adenylate cyclase in this area. This suggests that the serotonin-sensitive adenylate cyclase is associated with postsynaptic serotoninergic receptors in the brain. During development, in both the rat and the guinea pig, the amount of cyclic 3',5'-AMP formed in response to an optimal concentration of serotonin in a given area remained constant. This is in contrast to the amount of cyclic AMP formed in response to an optimal concentration of dopamine, which increased 6-fold in the rat striatum between the second and 23rd days after birth. The lack of correlation between the regional distribution of the dopamine-sensitive adenylate cyclase and serotoninergic innervation and between the serotonin-sensitive adenylate cyclase and dopaminergic innervation further emphasizes that the serotonin- and dopamine-sensitive adenylate cyclases are each associated with specific receptors in the rat brain.

Note:
ACKNOWLEDGMENT We thank Dr. J. Glowinski for many stimulating discussions during the preparation of the manuscript.

Submitted on May 5, 1977
Accepted on July 28, 1977




This article has been cited by other articles:


Home page
 ScienceHome page
S. Peroutka, R. Lebovitz, and S. Snyder
Two distinct central serotonin receptors with different physiological functions
Science, May 15, 1981; 212(4496): 827 - 829.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics