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Molecular Pharmacology, Vol 14, 215-219, Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics

Differences between Nuclear and Microsomal Cytochrome P-450 in Uninduced and Induced Rat Liver

ELEANOR ROGAN 1 and ERCOLE CAVALIERI 1

1 Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska 68105

Cytochrome P-450 in rat liver nuclei was distinguishable from that in the corresponding liver microsomes. Characterization was carried out using carbon monoxide and ethyl isocyanide binding difference spectra. Nuclear cytochrome P-450 in 3-methylcholanthrene-induced animals had different spectral properties from the nuclear cytochrome P-450 in uninduced and phenobarbital-induced animals. These spectral data demonstrate that hepatic nuclear cytochrome P-450 differs from the microsomal species.

Submitted on May 11, 1977
Accepted on September 12, 1977






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Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics