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Molecular Pharmacology, Vol 14, 220-224, Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics

The Inhibitory Effect of Aurintricarboxylic Acid on the Attachment of Ribosomes to Microsomal Membranes in Vitro

ELENA BUSSOLATI 1, RENATA BIDOGLIA 1, and NICA BORGESE 1

1 Consiglio Nazionale delle Ricerche Center of Cytopharmacology and Department of Pharmacology, University of Milan, Milan, Italy

Aurintricarboxylic acid was shown to inhibit the binding of ribosomes to rough microsomal membranes stripped of their ribosomes in a cell-free system derived from rat liver. The ED50 was equal to 65 µM. The inhibitory effect was due to the binding of aurintricarboxylic acid to some membrane component necessary for the attachment of ribosomes. 1-Anilinonaphthalene-8-sulfonic acid also inhibited ribosome binding, but higher concentrations of the drug were necessary.

Note:
ACKNOWLEDGMENT We thank Dr. Jacopo Meldolesi for helpful discussions.

Submitted on March 28, 1977
Accepted on June 29, 1977






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