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Molecular Pharmacology, Vol 14, 266-270, Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics

The Turnover Numbers of Acetylcholinesterase Forms

MICHAEL A. GORDON 1, DONALD E. CARPENTER 1, and IRWIN B. WILSON 1

1 Department of Chemistry, University of Colorado, Boulder, Colorado 80309

The turnover numbers of different acetylcholinesterase forms from electric eel, including the 18 S, 14 S, and 8 S asymmetrical forms and the 11 S lytic form, were measured using an extraordinarily active phosphorylating inhibitor, 7-(diethoxyphosphinyloxy)-N-methylquinolinium ion, as a titrating agent for the concentration of active sites. The 18 S and 14 S forms were about equally active. The 8 S and 11 S forms were about 35% more active than the 18 S and 14 S forms.

Submitted on June 21, 1977
Accepted on November 7, 1977




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