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Molecular Pharmacology, Vol 14, 717-721, Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics

Effect of Varying the Insulin to Glucagon Ratio on Porphyrin Biosynthesis in Chick Embryo Liver Cells

PETER W. F. FISCHER 1, JANET K. STEPHENS 1, and G. S. MARKS 1

1 Department of Pharmacology, Queen’s University, Kingston, Ontario K7L 3N6, Canada

Allylisopropylacetamide-induced porphyrin accumulation in chick embryo liver cells depends upon the insulin to glucagon ratio. A low level of porphyrin accumulation occurs at insulin to glucagon ratios similar to those found following glucose administration in vivo, suggesting a possible explanation for the therapeutic effect of glucose in hepatic porphyria.

Note:
ACKNOWLEDGMENT The authors thank Mrs. Frances Taylor for her skillful technical assistance.

Submitted on October 11, 1977
Accepted on February 2, 1978




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