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Molecular Pharmacology, Vol 14, 1130-1135, Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics

Inhibition of the Phosphorylation of Nonhistone Chromosomal Proteins by Cordycepin and Xylosyladenine in L1210 Cells in Vitro

MICHEL LEGRAVEREND 1 and ROBERT I. GLAZER 1

1 Laboratory of Medicinal Chemistry and Biology, National Cancer Institute, Bethesda, Maryland 20014

Cordycepin and xylosyladenine were tested for their inhibitory effect upon the phosphorylation of nuclear proteins in L1210 cells in vitro. As indicated by isoelectric focusing of urea-soluble nuclear proteins, the phosphorylation of acidic nonhistone chromosomal proteins was strongly inhibited by both nucleosides, particularly in the presence of the adenosine deaminase inhibitor, 2'-deoxycoformycin. These observations may explain, in part, the inhibitory effect of both drugs upon transcription.

Submitted on April 20, 1978
Accepted on June 13, 1978






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Copyright © 1978 by the American Society for Pharmacology and Experimental Therapeutics