MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MUKHTAR, H.
Right arrow Articles by BEND, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MUKHTAR, H.
Right arrow Articles by BEND, J. R.

Molecular Pharmacology, Vol 15, 192-196, Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics

Rat Hepatic Nuclear Cytochrome P-450 and Epoxide Hydrase in Membranes Prepared by Two Methods: Similarities with the Microsomal Enzymes

HASAN MUKHTAR 1, TAHANI H. ELMAMLOUK 1, RICHARD M. PHILPOT 1, and JOHN R. BEND 1

1 Laboratory of Pharmacology, National Institute of Environmental Health Sciences, P. O. Box 12233, Research Triangle Park, North Carolina 27709

Cytochrome P-450 in rat liver nuclear membranes of untreated, PB-pretreated, or 3-MC-pretreated animals was spectrally similar to corresponding liver microsomes. Epoxide hydrase activity of liver nuclear membrane and microsomes was induced by PB administration; 3-MC did not cause any induction. The same results were obtained when either the DNase digestion method or sucrose density centrifugation technique for preparation of nuclear membranes was used.

Submitted on August 3, 1978
Accepted on August 10, 1978




This article has been cited by other articles:


Home page
 Drug Metab. Dispos.Home page
D. J. Carlile, K. Zomorodi, and J. B. Houston
Scaling Factors to Relate Drug Metabolic Clearance in Hepatic Microsomes, Isolated Hepatocytes, and the Intact Liver. Studies with Induced Livers Involving Diazepam
Drug Metab. Dispos., August 1, 1997; 25(8): 903 - 911.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics