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Molecular Pharmacology, Vol 15, 678-684, Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics

1-Naphthylthiourea: A Mutagenic Rodenticide that Transforms Hamster Embryo Cells

J. C. KAWALEK 1, A. W. ANDREWS 1, and R. J. PIENTA 1

1 Chemical Carcinogenesis Program, NCI Frederick Cancer Research Center, Frederick, MD 21701

1-Naphthylthiourea is a rodenticide which produces pulmonary edema. It is mutagenic when metabolized by liver microsomal fractions from rats treated with either Aroclor 1254 or phenobarbital. It also transforms hamster embryo cells in an in vitro carcinogenesis bioassay.

Note:
ACKNOWLEDGMENT The authors wish to thank Corinthia Brown, Carl Valentine, Jan Reichard and James Fornwald for performing the Ames assay, William B. Lebherz III for the transformation bioassay, and Gail Hayslip and Nancy Forletta for typing this manuscript.

Submitted on August 18, 1978
Accepted on December 11, 1978






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