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Molecular Pharmacology, Vol 15, 747-750, Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics

Modification of Acetylcholine Receptor-Mediated Ion Permeability by Thiamine

DANIEL R. DOERGE 1, MARK G. MCNAMEE 1, and LLOYD L. INGRAHAM 1

1 Department of Biochemistry and Biophysics, University of California, Davis, California 95616

Thiamine has been found to be active in an acetylcholine receptor-rich postsynaptic membrane preparation from Torpedo californica electroplax by inhibiting the rate of carbamylcholine-induced acetylcholine receptor-mediated 22Na efflux. Thiamine reduces the maximal response to carbamylcholine without changing the affinity of the receptor for carbamylcholine.

Submitted on July 24, 1978
Accepted on November 21, 1978






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Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics