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Molecular Pharmacology, Vol 15, 751-753, Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics

Stereospecific Opiate Binding in Bovine Adrenal Medulla

CHARLES CHAVKIN 1, B. M. Cox 1, and AVRAM GOLDSTEIN 1

1 Stanford University and Addiction Research Foundation, 701 Welch Road, Palo Alto, California 94304

In this report we describe a population of high affinity, saturable, opiate binding sites in the adrenal medulla. These sites show the typical sensitivity to sodium ions characteristic of opiate binding sites found in brain tissue. No comparable high affinity sites were detectable in adrenal cortex.

Submitted on October 27, 1978
Accepted on December 16, 1978






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