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Molecular Pharmacology, Vol 16, 306-312, Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics

Enhanced Glycosylation Induced by Adriamycin

DAVID KESSEL 1

1 Departments of Oncology and Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201

Within 30 min of exposure of P388 murine leukemia cells to the anthracycline anti-tumor drug adriamycin, cell-surface electronegativity and incorporation of radioactive fucose into membrane glycoproteins were markedly increased, while cell surface hydrophobicity and incorporation of thymidine into DNA decreased. Incorporation of labeled leucine into cell protein was unaffected. These data indicate a drug-induced increase in production of electronegative and hydrophilic membrane glycoproteins which was not found when adriamycin-resistant cells were similarly treated.

Note:
ACKNOWLEDGMENT Excellent technical assistance by Gwynne Smith and Kenneth Kohn is acknowledged, along with the providing of material in advance of publication by Dr. R. K. Johnson, Arthur D. Little Corp., Cambridge, Mass.

Submitted on October 16, 1978
Accepted on January 15, 1979




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