MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KALYANARAMAN, B.
Right arrow Articles by HOLTZMAN, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KALYANARAMAN, B.
Right arrow Articles by HOLTZMAN, J. L.

Molecular Pharmacology, Vol 16, 1059-1064, Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics

Electron Spin Resonance Evidence for a Free Radical Intermediate in the Cis-Trans Isomerization of Furylfuramide by Oxygen-Sensitive Nitroreductases

B. KALYANARAMAN 1, EDWARD PEREZ-REYES 1, RONALD P. MASON 1, FRANCIS J. PETERSON 2, and JORDAN L. HOLTZMAN 2

1 National Institute of Environmental Health Science, Laboratory of Environmental Biophysics, P.O. Box 12233, Research Triangle Park, N.C. 27709
2 Research Service, Veterans Administration Hospital, Minneapolis, Minnesota 55417 and Departments of Medicine and Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455

Tatsumi et al. proposed that the enzymatic cis-trans1 isomerization of furylfuramide is the result of anion free radical formation by nitroreductases. Electron spin resonance measurements of the furylfuramide anion free radical have provided spectral evidence of this intermediate, and clarified the disputed relationship between the isomerization and the nitro reduction of furylfuramide.

Submitted on March 15, 1979
Accepted on May 23, 1979






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics