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Molecular Pharmacology, Vol 16, 922-931, Copyright © 1979 by the American Society for Pharmacology and Experimental Therapeutics

Genetic Analysis of Serum Dopamine-Beta-Hydroxylase Activity in Rats

JON M. STOLK 1, JEFFREY H. HURST 1, DEE A. VAN RIPER 1, and PETER Q. HARRIS 1

1 Neuroscience Program, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228 and Departments of Psychiatry and Pharmacology, Dartmouth Medical School, Hanover, NH 03755

The inheritance of serum dopamine-beta-hydroxylase activity was studied using Mendelian crosses derived from four inbred rat strains. Serum enzyme activity is inherited as an autosomal co-dominant trait in female rats. In males, however, serum dopamine-beta-hydroxylase activity is inherited as if it were an autosomal dominant trait, with low activity being dominant over high activity, indicating that sex-related modifiers of serum enzyme activity are present in rats. The contribution of sex-linked inheritance to serum dopamine-beta-hydroxylase activity is suggested by the data.

Note:
ACKNOWLEDGMENTS The expert technical assistance of Madelyn Stolk, Thomas Byrne and Dr. David Cooper is gratefully acknowledged. Drs. Mary Lee Ledbetter and Ian Bush provided helpful suggestions in the analysis and interpretation of the data. Finally, the advice and assistance by the staff at Microbiological Associates, Inc. were most helpful in establishing the breeding colonies.

Submitted on February 5, 1979
Accepted on July 9, 1979






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