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Molecular Pharmacology, Vol 18, 550-552, Copyright © 1980 by the American Society for Pharmacology and Experimental Therapeutics

Nucleolar Cytochrome P-450

EDWARD BRESNICK 1, BRUCE HASSUK 1, PAUL LIBERATOR 1, WAYNE LEVIN 2, and PAUL E. THOMAS 2

1 Department of Biochemistry and The Vermont Regional Cancer Center, The University of Vermont College of Medicine, Burlington, Vermont 05405
2 Department of Biochemistiy and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110

Significant amounts of cytochrome P-450 have been detected spectrally in purified nucleoli obtained from the livers of 3-methylcholanthrene-treated rats. Using monospecific antibody to microsomal cytochrome P-450c (P-448), we have shown that the nucleolar and microsomal enzymes are immunochemically identical. These nucleoli also contained epoxide hydrolase and NADPH-cytochrome c reductase activities, both of which were immunochemically identical to their respective microsomal counterparts.

Submitted on January 22, 1980
Accepted on May 19, 1980






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