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Molecular Pharmacology, Vol 18, 565-570, Copyright © 1980 by the American Society for Pharmacology and Experimental Therapeutics

Differential Induction by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin of Multiple Forms of Rabbit Microsomal Cytochrome P-450: Evidence for Tissue Specificity

HENG H. LIEM 1, URSULA MULLER-EBERHARD 1, and ERIC F. JOHNSON 1

1 Department of Biochemistsy, Scripps Clinic and Research Foundation, La Jolla, California 92037

Four forms of cytochrome P-450, forms 2, 3, 4, and 6, are presently being isolated and characterized in this laboratory. Induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin of specific forms of microsomal cytochrome P-450 was studied in adult rabbit kidney and lung. The induction of a single prominent cytochrome P-450 form was observed; this cytochrome was identified as form 6. The assigmnent of the inducible pulmonary and renal cytochrome as form 6 was established by its mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, its peptide map, and its specific antigenicity. In contrast, previous findings have shown that form 4 is the major cytochrome P-450 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in adult rabbit liver. Thus, the specific induction of cytochrome P-450 forms 4 and 6 is tissue dependent.

Note:
ACKNOWLEDGMENTS The technical assistance of Maria Balga, Maryann Zounes, and Kendis Cox is gratefully acknowledged. We wish to thank Diane Montoya and Pat Matson for preparation of the manuscript.

Submitted on March 24, 1980
Accepted on June 16, 1980




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