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Molecular Pharmacology, Vol 19, 184-186, Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics

Comparative Flavoprotein Catalysis of Anthracycline Antibiotic

Reductive Cleavage and Oxygen Consumption

SU-SHU PAN 1, LESLIE PEDERSEN 1, and NICHOLAS R. BACHUR 1

1 Laboratory of Clinical Biochemistry, Baltimore Cancer Research Program, Division of Cancer Treatment, National Cancer Institute, Baltimore, Maryland 21201

Several flavoenzymes are compared for their ability to catalyze reductive glycosidic cleavage of anthracycline antibiotics and to promote oxygen consumption in the presence of the antibiotics. NADPH cytochrome P-450 reductase, xanthine oxidase, nitrate reductase, NADH cytochrome c reductase, and lipoamide dehydrogenase catalyzed with decreasing specific activity the reductive glycosidic cleavage of daunorubicin and showed enhanced oxygen consumption in the presence of daunorubicin. Gluthione reductases, L-amino acid oxidase, D-amino acid oxidase, D-glucose oxidase, and lactic dehydrogenase were inactive. All of those flavoenzymes which catalyze reductive glycosidic cleavage possess single-electron transfer systems.

Note:
ACKNOWLEDGMENT We wish to thank Ms. Helen Chlewicki in the preparation of the manuscript.

Submitted on April 11, 1980
Accepted on September 2, 1980




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