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Molecular Pharmacology, Vol 19, 56-61, Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics

Solubility of Inhalation Anesthetics in Various Media

A New Correlation

S. ALEXANDER STERN 1 and SHII-PYNG SHIAH 1

1 Department of Chemical Engineering and Materials Science, Syracuse University, Syracuse, New York 13210

A new correlation for the solubility of inhalation anesthetics and other gases and vapors in lipid phases, polymers, and other media is derived from thermodynamic considerations. The correlation is applicable to solute concentrations in Henry’s law limit, such as is the case for clinical concentrations of anesthetics. Ostwald solubility coefficients for a variety of anesthetics and light gases in lipids, rubber, and silicone rubber were correlated over a range of 6 orders of magnitude in solubility values. The proposed correlation should prove useful for estimating solubility coefficients of gases and vapors in a variety of media, as well as the temperature dependence of these coefficients.

Note:
ACKNOWLEDGMENT The contribution of Dr. S.-M. Fang is gratefully acknowledged.

Submitted on June 9, 1980
Accepted on August 12, 1980






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