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Molecular Pharmacology, Vol 19, 520-524, Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics

Inhibition of Synthesis of Lung Proteins by Halothane

SUE A. WARTELL 1, ROSE CHRISTOPHERSON 1, CLYDE A. WATKINS 1, and D. EUGENE RANNELS 1

1 Departments of Physiology and Anesthesia, The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania 17033

The effect of halothane exposure on synthesis of lung proteins was investigated. In rat lungs perfused in situ with Krebs-Henseleit bicarbonate buffer containing plasma levels of 19 amino acids, 690 µM [14C]phenylalanine, 5.6 mM glucose, and 4.5% bovine serum albumin, protein synthesis was linear for at least 4 hr. Halothane (1-4% equilibrated with O2/N2/CO2, 4:15:1) rapidly inhibited protein synthesis in a dose-dependent manner, with about a 10% depression of the rate for each 1% increment in halothane. The inhibition was rapidly and completely reversed when halothane delivery was stopped; it was not associated with depletion of tissue ATP or with nonspecific changes in cellular permeability. A similar reversible and dose-dependent inhibition of protein synthesis was observed in primary cultures of mixed lung cells incubated in Dulbecco’s minimal essential medium containing 10% donor calf serum. These results suggested a significant but reversible inhibition of protein synthesis, exerted at the cellular level, in lungs exposed to halothane.

Note:
ACKNOWLEDGMENT The authors thank Ms. Patricia A. Gering for typing the manuscript.

Submitted on November 12, 1980
Accepted on January 21, 1981




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