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Molecular Pharmacology, Vol 20, 227-229, Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics

Proteolytic Susceptibility of Hemoglobin Synthesized in the Presence of Amino Acid Analogues

SABURO AYUKAWA 1, JOYCE M. FISHER 1, and MARCO RABINOVITZ 1

1 Laboratory of Medicinal Chemistry and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205

agr-Amino acid analogues with a hetero atom on the beta-carbon, when incorporated into protein by a reticulocyte lysate, render the newly formed protein particularly sensitive to proteolytic hydrolysis.

Submitted on October 23, 1980
Accepted on March 16, 1981






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