MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MENNINI, T.
Right arrow Articles by SAMANIN, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MENNINI, T.
Right arrow Articles by SAMANIN, R.

Molecular Pharmacology, Vol 20, 237-239, Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics

Changes in Serotonin, but Not Catecholamine, Receptor Binding in the Brain of Morphine-Dependent Rats

TIZIANA MENNINI 1, ELENA POGGESI 1, SUSANNA COTECCHIA 1, ANTONIO DE BLASI 1, and ROSARIO SAMANIN 1

1 Istituto di Ricerche Farmacologiche "Mario Negri," 62-20157 Milan, Italy

Chronic morphine administration causes a 40% reduction of 3H-labeled 5-hydroxytryptamine (5-HT) binding in the brain stems of dependent rats, with little or no effect in other brain regions. Binding of [3H]dihydroalprenolol, 2,2,6-[3H]dimethoxyphenoxy-(ethylaminomethyl)benzodioxan, and [3H]spiroperidol is not affected by this treatment. The specificity of the reduction in 5-HT receptor number in the brain stem is discussed in terms of persistent activation of central 5-HT neurons by long-term treatment with morphine.

Submitted on October 27, 1980
Accepted on May 20, 1981






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics