MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by WEISS, S.
Right arrow Articles by DRUMMOND, G. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by WEISS, S.
Right arrow Articles by DRUMMOND, G. I.

Molecular Pharmacology, Vol 20, 592-597, Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics

Dopamine- and Serotonin-Sensitive Adenylate Cyclase in the Gill of Aplysia californica

SAM WEISS 1 and GEORGE I. DRUMMOND 1

1 University Biochemistry Group, Division of Biochemistry, Department of Chemistry, University of Calgary, Calgary T2N 1N4 Canada

Stimulation of adenylate cyclase by dopamine and serotonin was examined in a particulate fraction of Aplysia gill homogenates. Dopamine augmented activity 3- to 5-fold (EC50, 10 µM), whereas serotonin increased activity 15- to 20-fold (EC50, 1 µM). Lysergic acid diethylamide and several ergot alkaloids were full or partial agonists for enzyme stimulation. Structure-activity relationships of dopaminergic and serotonergic stimulation and the blocking action of several antagonists suggest that structural similarities exist between the receptors that mediate dopamine and serotonin stimulation of adenylate cyclase.

Note:
ACKNOWLEDGMENTS The authors thank Dr. Ken Lukowiak and his graduate students, Jeff I. Goldberg and Peter C. Ruben, for providing gill tissue samples and for many thoughtful suggestions throughout the course of the study.

Submitted on May 7, 1981
Accepted on July 27, 1981




This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
E. A. Kabotyanski, D. A. Baxter, S. J. Cushman, and J. H. Byrne
Modulation of Fictive Feeding by Dopamine and Serotonin in Aplysia
J Neurophysiol, January 1, 2000; 83(1): 374 - 392.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
S Morris, P Greenaway, A. Adamczewska, and M. Ahern
Adaptations to a terrestrial existence in the robber crab Birgus latro L. IX. Hormonal control of post-renal urine reprocessing and salt balance in the branchial chamber
J. Exp. Biol., January 1, 2000; 203(2): 389 - 396.
[Abstract] [PDF]

Home page
 J. Neurosci.Home page
G. Feng, F. Hannan, V. Reale, Y. Y. Hon, C. T. Kousky, P. D. Evans, and L. M. Hall
Cloning and Functional Characterization of a Novel Dopamine Receptor from Drosophila melanogaster
J. Neurosci., June 15, 1996; 16(12): 3925 - 3933.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics