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Adrenergic ligand liposolubility in membranes. Direct assessment in a beta-adrenergic binding system

EM Dax and JS Partilla

The binding of [3H]dihydroalprenolol to adipocyte membranes may be displaced not only from beta-adrenergic receptors but also nonstereospecifically from other membrane compartments by beta- adrenergic and other adrenergic agents. The EC50 of this nonstereospecific displaceable binding is directly related to the liposolubility (n-octanol:water partition coefficient) of the displacing ligand.

Volume 22, Issue 1, pp. 5-7, 07/01/1982
Copyright © 1982 by American Society for Pharmacology and Experimental Therapeutics




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P. Damier, A. Kastner, Y. Agid, and E. C. Hirsch
Does monoamine oxidase type B play a role in dopaminergic nerve cell death in Parkinson's disease?
Neurology, May 1, 1996; 46(5): 1262 - 1262.
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Copyright © 1982 by the American Society for Pharmacology and Experimental Therapeutics