MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harrelson, W.
Right arrow Articles by Mason, R. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harrelson, W.
Right arrow Articles by Mason, R. P.

Microsomal reduction of gentian violet. Evidence for cytochrome P-450- catalyzed free radical formation

WG Harrelson and RP Mason

The triarylmethane dye, gentian violet, is shown to undergo a one- electron reduction by the cytochrome P-450 monooxygenase system to produce a carbon-centered free radical as demonstrated by direct electron spin resonance techniques. The formation of this species is inhibited by carbon monoxide and metyrapone, suggesting the involvement of cytochrome P-450. Either NADPH or NADH can serve as a source of reducing equivalents for the production of this free radical. Related triarylmethane dyes are also shown to be reduced by the monooxygenase system to form free radicals.

Volume 22, Issue 2, pp. 239-242, 09/01/1982
Copyright © 1982 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
J. J. Jones and J. O. Falkinham III
Decolorization of Malachite Green and Crystal Violet by Waterborne Pathogenic Mycobacteria
Antimicrob. Agents Chemother., July 1, 2003; 47(7): 2323 - 2326.
[Abstract] [Full Text] [PDF]

Home page
 Appl. Environ. Microbiol.Home page
C.-J. Cha, D. R. Doerge, and C. E. Cerniglia
Biotransformation of Malachite Green by the Fungus Cunninghamella elegans
Appl. Envir. Microbiol., September 1, 2001; 67(9): 4358 - 4360.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R Docampo, S. Moreno, R. Muniz, F. Cruz, and R. Mason
Light-enhanced free radical formation and trypanocidal action of gentian violet (crystal violet)
Science, June 17, 1983; 220(4603): 1292 - 1295.
[Abstract] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1982 by the American Society for Pharmacology and Experimental Therapeutics