MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liehr, J. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liehr, J. G.

2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity

JG Liehr

Estrogenic and carcinogenic activity are shown to be separable properties. 2-Fluoroestradiol, a modified estrogen, did not induce renal clear-cell carcinoma in male Syrian hamsters despite its estrogenic potency, which is comparable to that of estradiol. 4- Fluoroestradiol, also a potent estrogen, did induce renal clear-cell carcinoma in this animal model, but more slowly than estradiol. 2,4- Dideuterioestradiol was found to be as estrogenic and also as carcinogenic as estradiol itself.

Volume 23, Issue 2, pp. 278-281, 03/01/1983
Copyright © 1983 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
H. K. Bhat, G. Calaf, T. K. Hei, T. Loya, and J. V. Vadgama
Critical role of oxidative stress in estrogen-induced carcinogenesis
PNAS, April 1, 2003; 100(7): 3913 - 3918.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. G. Liehr
Is Estradiol a Genotoxic Mutagenic Carcinogen?
Endocr. Rev., February 1, 2000; 21(1): 40 - 54.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1983 by the American Society for Pharmacology and Experimental Therapeutics