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Interaction of metal-complexing compounds with lymphocytes and lymphoid cell lines

G Jung, G Hennings, M Pfeifer and WG Bessler

A variety of metal-complexing flavonoids (beta-hydroxyethyl rutoside, catechin, naringin, taxifolin, and quercetin) as well as several compounds which form mainly iron complexes (bathophenathroline, bathophenanthrolinebisulfonic acid, desferri-ferrioxamine B, ethylenediamine-di-o-hydroxyphenylacetic acid) were tested for their effects on mitogen-free and mitogen-activated mouse splenocyte cell cultures and on two human cell lines (Daudi, Bristol-8). The compounds strongly inhibited the incorporation of [3H]thymidine into DNA at agent concentrations ranging from 10 to 500 microM. On the other hand, at subinhibitory concentrations, slightly enhancing or synergistic effects were observed. We conclude that immune cell behavior can be bidirectionally influenced by the presence of metal-complexing agents, depending on their concentration in the medium.

Volume 23, Issue 3, pp. 698-702, 05/01/1983
Copyright © 1983 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1983 by the American Society for Pharmacology and Experimental Therapeutics