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Molecular Pharmacology, Vol 3, 9-14, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

Reactions of N,N-Dimethylaniline-N-oxide with Hemoglobin

MANFRED KIESE 1

1 Pharmakologisches Institut der Universität München, Munich, Germany

N,N-Dimethylaniline-N-oxide reduces ferrihemoglobin (methemoglobin) under anaerobic conditions. In solutions of hemoglobin and N,N-dimethylaniline-N-oxide under air ferrihemoglobin is formed. Oxygen is necessary for this reaction. After a short lag phase the reaction rapidly increases in rate. Partial oxidation of the hemoglobin accelerates the reaction. Reagents which react with —SH groups also accelerate thue reaction. However, the "autocatalytic" course is retained after the —SH groups are blocked.

Note:
ACKNOWLEDGMENT The author is grateful to Miss Maria Arnold and Miss Luise Richter for competent technical assistance.

Submitted on July 12, 1966






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