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Molecular Pharmacology, Vol 3, 216-218, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

Estimation of the Turnover Rate of Barbiturate Side-Chain Oxidation Enzyme in Rat Liver

IRWIN M. ARIAS 1 and ANTONIO DE LEON 1

1 Department of Medicine and the Unit for Research in Aging, Albert Einstein College of Medicine and The Bronx Municipal Hospital Center, New York, New York

Hepatic side-chain oxidation of hexobarbital was estimated in rats before, during, and after administration of sodium phenobarbital in increasing dosage for 1 to 84 days. The half-life of the enzyme was virtually the same during and after drug administration. These results indicate that phenobarbital increases synthesis of the enzyme, and they illustrate the estimation of enzyme degradation by analysis of the change in enzyme level from one steady state to another.

Note:
This work was supported by Research Grants from time United States Public Health Service (AM-02019 and HD-00674).

Submitted on January 9, 1967






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