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Molecular Pharmacology, Vol 3, 254-265, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

Mechanism of Secretion from the Adrenal Medulla

II. Release of Catecholamines and Storage Vesicle Protein in Response to Chemical Stimulation

N. KIRSHNER 1, H. J. SAGE 1, and W. J. SMITH 1

1 Departments of Biochemistry and Pathology Duke University Medical Center, Durham, North Carolina 27706

The release of catecholamines and a specific protein of the storage vesicles was measured in isolated perfused bovine adrenal glands. Stimulation of catecholamine secretion by acetylcholine, nicotine, or Ba++ caused a parallel increase in the secretion of the storage vesicle protein. The ratio of catecholamines: vesicle protein in the perfusates was, within the limits of experimental error, the same as that in the intact gland. The release of both the vesicle protein and the catecholamines required Ca++ and was temperature dependent. These studies provide additional evidence to support the hypothesis that catecholamines are secreted from the medulla by a process in which the storage vesicle contents are released directly to the exterior of the cell.

Note:
ACKNOWLEDGMENT This work was supported by grants AM-0542 and AI-06710 from the National Institutes of Health.

Submitted on December 19, 1966






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