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Molecular Pharmacology, Vol 3, 274-278, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics
1 Experimental Therapeutics Branch, National Heart Institute, National Institutes
of Health, Bethesda, Maryland 20014
Administration of the specific serotonin depletor p-chlorophenylalanine to rats results in marked inhibition of tryptophan hydroxylase of the brain. The enzyme inhibition can be correlated with and is assumed to be responsible for brain serotonin depletion. Although p-chlorophenylalanine is a competitive inhibitor of tryptophan hydroxylase in vitro, it causes an irreversible inactivation of the enzyme in vivo. The findings also support the conclusion that tryptophan hydroxylation is the rate-limiting enzymic step in serotonin biosynthesis.
Note:
ACKNOWLEDGMENT
The authors would like to thank Dr. Sidney
Udenfriend for helpful discussions during the
course of this work.
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