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Molecular Pharmacology, Vol 3, 284-289, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

The Binding of Noradrenaline to Phosphatidylserine. In Vitro Studies of an Artificial Model System of Biological Origin

BENT FORMBY 1

1 The Neurochemical Institute, The Danish Multiple Sclerosis Society, Copenhagen, Denmark

Phosphatidylserine chromatographically purified from human hypothalamus shows a high capacity to bind nonionized noradrenaline in vitro. Experimental results from a two-phase model, consisting of an aqueous phase with noradrenaline and a lipophilic organic phase containing the purified lipid, are found to agree with theoretical predictions on the effects of pH and concentration on binding capacity. The results make it possible to suggest a mechanism for the transport of noradrenaline through the membranes of the brain.

Submitted on October 31, 1966
Revised on February 27, 1967






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Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics