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Molecular Pharmacology, Vol 3, 303-305, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

Metabolic Integrity of Deoxyribonucleohistones during Enzyme Induction

PAUL BYVOET 1

1 Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida

Previous work has shown that after individual labeling of histone and DNA of various normal and neoplastic tissues of the rat, the first-order decay rates of their respective specific activities were approximately similar.

The present studies indicate that the normal turnover of histones in liver parenchymal cells is not altered during periods of alternate enzyme induction and repression resulting from dietary changes or drug injections.

Note:
ACKNOWLEDGMENTS This research was supported by U. S. National Institutes of Health Grant CA-18402, CY-6506 and an American Cancer Society Institutional Grant.

Submitted on January 30, 1967
Revised on March 27, 1967






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