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Molecular Pharmacology, Vol 3, 423-428, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

SH-Groups Essential for Estrogen Uptake and Retention in the Mouse Uterus

LARS TERENIUS 1

1 Department of Pharmacology, University of Uppsala, Sweden

The effect of various sulfhydryl reagents on the uptake and retention of estrogens by the mouse uterus in vitro has been studied. It was found that N-ethylmaleimide and p-chloromercuribenzoate blocked the uptake and retention of 17beta-estradiol by the uterus in vitro while iodoacetate blocked the uptake but not the retention of 17beta-estradiol. N-Ethylmaleimide also blocked the uterine uptake and retention of the synthetic estrogen meso-hexestrol. On the other hand, it had no effect on the uptake and retention of the less estrogenic stereoisomer racemic-hexestrol. Estrogen concentration in a "nontarget" tissue, the diaphragm, was essentially unaffected by the sulfhydryl inhibitors.

Note:
ACKNOWLEDGMENTS I would like to thank Mrs. Carola Engström for excellent technical assistance. The work was supported by a grant from the Swedish Cancer Society.

Submitted on March 13, 1967




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E. V. Jensen and E. R. DeSombre
Estrogen-Receptor Interaction: Estrogenic hormones effect transformation of specific receptor proteins to a biochemically functional form
Science, October 12, 1973; 182(4108): 126 - 134.
[Abstract] [PDF]


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