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Molecular Pharmacology, Vol 3, 453-472, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

The Mode of Action of Levallorphan as an Inhibitor of Cell Growth

RICHARD GREENE 1 and BORIS MAGASANIK 1

1 Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Levallorphan inhibits the synthesis of RNA, DNA, and protein by Escherichia coli. The drug was found to cause an immediate, dramatic decrease in the amount of intracellular ATP. Evidence is presented which suggests that the decrease in ATP concentration is a consequence of the stimulation of an ATPase. Similar results were obtained in HeLa cells treated with levallorphan.

Note:
ACKNOWLEDGMENT This work was supported by Research Grants CY-5210 and GM-7446 from the U.S. Public Health Service. During the course of this work Richard Green was the recipient of a Postdoctoral Fellowship 1 F2 AM-19,349 of the U.S. Public Health Service.

Submitted on April 20, 1967




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