Molecular Pharmacology, Vol 3, 595-598, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

Differential Inhibitors of tRNA Methylases

¹ Department of Biochemistry, Columbia University, College of Physicians and Surgeons, New York, New York 10032

The enzymes that methylate tRNA have qualitative and quantitative differences among different species. Inhibitors of these enzymes with three different specificities have been found: some restricted to bacterial enzymes, some to mammalian enzymes, and some with dual potencies.

Note:
ACKNOWLEDGMENTS We are indebted to Dr. Ross H. Hall for a generous gift of isopentenyl adenosine, and to Dr. Gunther S. Fouken of the Upjohn Company for the tubercidin. Time research was supported by grants from time National Institutes of Health and the U.S. Atomic Energy Commission.