MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Seeman, P.
Right arrow Articles by Guan, H. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Seeman, P.
Right arrow Articles by Guan, H. C.

Dopamine D1 and D2 receptors are sensitive to the cationic form of apomorphine

P Seeman and HC Guan

Department of Pharmacology, University of Toronto, Canada.

The protonated form of apomorphine was found to be active at the high affinity state of dopamine D1 and D2 receptors in canine striatum, since pH reduction from 7.4 to 6.4 enhanced the apomorphine potency 3- fold at both these sites without affecting the potency of the permanently charged apomorphine methiodide. It was estimated that the protonated form of apomorphine was approximately 20-fold more potent than the uncharged form of apomorphine at both the D1 and the D2 receptors.

Volume 32, Issue 6, pp. 760-763, 12/01/1987
Copyright © 1987 by American Society for Pharmacology and Experimental Therapeutics






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1987 by the American Society for Pharmacology and Experimental Therapeutics