MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Verma, A.
Right arrow Articles by Snyder, S. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Verma, A.
Right arrow Articles by Snyder, S. H.

Characterization of porphyrin interactions with peripheral type benzodiazepine receptors

A Verma and SH Snyder

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

We have examined organ and species variations in interactions of porphyrins with peripheral-type benzodiazepine receptors and explored structure-activity requirements for porphyrin-receptor interactions. Whereas potency of the benzodiazepine RO5-4864 varies several orders of magnitude in competing for receptors in different organs and species, effects of porphyrins and the isoquinoline carboxamide PK11195 are relatively constant. The structural requirements determining porphyrin affinity for benzodiazepine binding sites are fairly strict. The most potent porphyrins are those with prominent physiological functions.

Volume 34, Issue 6, pp. 800-805, 12/01/1988
Copyright © 1988 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 J. Exp. Med.Home page
H. Everett, M. Barry, X. Sun, S. F. Lee, C. Frantz, L. G. Berthiaume, G. McFadden, and R. C. Bleackley
The Myxoma Poxvirus Protein, M11L, Prevents Apoptosis by Direct Interaction with the Mitochondrial Permeability Transition Pore
J. Exp. Med., November 4, 2002; 196(9): 1127 - 1140.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
M. Gavish, I. Bachman, R. Shoukrun, Y. Katz, L. Veenman, G. Weisinger, and A. Weizman
Enigma of the Peripheral Benzodiazepine Receptor
Pharmacol. Rev., December 1, 1999; 51(4): 629 - 650.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. G. Pastorino, G. Simbula, K. Yamamoto, P. A. Glascott Jr., R. J. Rothman, and J. L. Farber
The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition
J. Biol. Chem., November 22, 1996; 271(47): 29792 - 29798.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1988 by the American Society for Pharmacology and Experimental Therapeutics