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Ribavirin is an inhibitor of human immunodeficiency virus reverse transcriptase

R Fernandez-Larsson and JL Patterson

Division of Infectious Diseases, Children's Hospital, Boston, Massachusetts.

Ribavirin inhibits the human immunodeficiency virus reverse transcriptase in an in vitro reaction. Ribavirin-5'-diphosphate was close to 40% more inhibitory than ribavirin-5'-triphosphate. Unphosphorylated ribavirin had a reduced, but detectable, effect as an inhibitor, compared with the phosphorylated forms. The compounds seem to have a direct effect on the viral polymerase, and no chain termination was observed in the presence of ribavirin-5'-triphosphate. Combination of any of the ribavirin derivatives tested with 3'-azido-3'- deoxythymidine (zidovudine)-5'-triphosphate resulted in an increase of its anti-human immunodeficiency virus reverse transcriptase activity in the in vitro assay.

Volume 38, Issue 6, pp. 766-770, 12/01/1990
Copyright © 1990 by American Society for Pharmacology and Experimental Therapeutics




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I. Bougie and M. Bisaillon
Initial Binding of the Broad Spectrum Antiviral Nucleoside Ribavirin to the Hepatitis C Virus RNA Polymerase
J. Biol. Chem., December 26, 2003; 278(52): 52471 - 52478.
[Abstract] [Full Text] [PDF]


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