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Molecular Pharmacology, Vol 4, 104-107, Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics

Conformational Changes of Acetylcholinesterase

RICHARD J. KITZ 1 and LEON T. KREMZNER 1

1 Departments of Anesthesiology, Biochemistry and Neurology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

The conformation of highly purified acetylcholinesterase was measured with a spectropolarimeter. It was demonstrated that heat, strong base, a substrate, and anticholinesterase agents induce alterations in the conformation of this enzyme.

Note:
ACKNOWLEDGMENT This study was supported in part by National Institutes of Health grants GM09069-05, NB 05184, and PH 446454; and National Science Foundation grant GB 5362.

Submitted on October 4, 1967






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