MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SNYDER, S. H.
Right arrow Articles by EPPS, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SNYDER, S. H.
Right arrow Articles by EPPS, L.

Molecular Pharmacology, Vol 4, 187-195, Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics

Regulation of Histidine Decarboxylase in Rat Stomach by Gastrin: the Effect of Inhibitors of Protein Synthesis

SOLOMON H. SNYDER 1 and LEON EPPS 1

1 Departments of Pharmacology and Experimental Therapeutics and Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Histidine decarboxylase activities in the stomachs of freely feeding rats or fasted rats treated with gastrin are 3 and 2 times, respectively, greater than enzyme activity of fasted rats. Administration of gastrin produces a marked increase of gastric histidine decarboxylase in 30 min with maximal effects between 2 and 3 hr, and a decline of enzyme activity to fasting levels after 8 hr. Puromycin and cycloheximide completely prevent the rise of gastric histidine decarboxylase activity induced by gastrin, whereas actinomycin D tends to stimulate this rise in activity. When cycloheximide is administered to freely feeding rats there is an exponential fall in gastric histidine decarboxylase activity with a half-life of 2.1 hr. Cycloheximide treatment accelerates the decline of gastric histidine decarboxylase activity after enhancement by gastrin.

Note:
ACKNOWLEDGMENT This research was supported by USPHS grants TO 1-MH-11267 and 1 RO1 NB 07275. Solomon H. Snyder is a recipient of NIMH Research Career Development Award 5 KO3-MH-33128.

Submitted on October 4, 1967
Revised on December 27, 1967






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics